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Sulfation of 12-hydroxy-nevirapine by human SULTs and the effects of genetic polymorphisms of SULT1A1 and SULT2A1.
Kurogi K, Cao Y, Segawa K, Sakakibara Y, Suiko M, Uetrecht J, Liu MC. Kurogi K, et al. Biochem Pharmacol. 2022 Oct;204:115243. doi: 10.1016/j.bcp.2022.115243. Epub 2022 Sep 6. Biochem Pharmacol. 2022. PMID: 36084709
Enzymatic assays revealed that of the thirteen human SULTs, SULT1A1 and SULT2A1 displayed strong 12-OH-NVP-sulfating activity. 1-Phenyl-1-hexanol (PHHX), which applied topically prevents the skin rash in rats, inhibited 12-OH-NVP sulfation by SULT1A1 and SULT …
Enzymatic assays revealed that of the thirteen human SULTs, SULT1A1 and SULT2A1 displayed strong 12-OH-NVP-sulfating activity. 1-Phen …
Interactions of cytosolic sulfotransferases with xenobiotics.
James MO, Ambadapadi S. James MO, et al. Drug Metab Rev. 2013 Nov;45(4):401-14. doi: 10.3109/03602532.2013.835613. Drug Metab Rev. 2013. PMID: 24188364 Review.
The human cytosolic sulfotransferases that have been most studied, namely SULT1A1, SULT1A3, SULT1B1, SULT1E1 and SULT2A1, are expressed in different tissues of the body, including liver, intestine, adrenal, brain and skin. ...
The human cytosolic sulfotransferases that have been most studied, namely SULT1A1, SULT1A3, SULT1B1, SULT1E1 and SULT2A1, are express …
Comparison of xenobiotic metabolizing enzyme activities in ex vivo human skin and reconstructed human skin models from SkinEthic.
Eilstein J, Léreaux G, Budimir N, Hussler G, Wilkinson S, Duché D. Eilstein J, et al. Arch Toxicol. 2014 Sep;88(9):1681-1694. doi: 10.1007/s00204-014-1218-6. Arch Toxicol. 2014. PMID: 24658324
In vitro engineered human skins have been developed to replace limited ex vivo normal human skin samples (NHS). Thus, assessing and comparing skin models from SkinEthic [Episkin, RHE and the full thickness model (FTM)] with NHS in terms of metabolic capability are e …
In vitro engineered human skins have been developed to replace limited ex vivo normal human skin samples (NHS). Thus, assessing and c …
Effects of human sulfotransferases on the cytotoxicity of 12-hydroxynevirapine.
Fang JL, Loukotková L, Chitranshi P, Gamboa da Costa G, Beland FA. Fang JL, et al. Biochem Pharmacol. 2018 Sep;155:455-467. doi: 10.1016/j.bcp.2018.07.016. Epub 2018 Jul 18. Biochem Pharmacol. 2018. PMID: 30028994
Nevirapine, a non-nucleoside reverse transcriptase inhibitor used for the treatment of AIDS, can cause serious skin rashes and hepatotoxicity. Previous studies have indicated that the benzylic sulfate 12-sulfoxynevirapine, the formation of which is catalyzed by human sulfo …
Nevirapine, a non-nucleoside reverse transcriptase inhibitor used for the treatment of AIDS, can cause serious skin rashes and hepato …
Sulfotransferase-1A1-dependent bioactivation of aristolochic acid I and N-hydroxyaristolactam I in human cells.
Hashimoto K, Zaitseva IN, Bonala R, Attaluri S, Ozga K, Iden CR, Johnson F, Moriya M, Grollman AP, Sidorenko VS. Hashimoto K, et al. Carcinogenesis. 2016 Jul;37(7):647-655. doi: 10.1093/carcin/bgw045. Epub 2016 Apr 18. Carcinogenesis. 2016. PMID: 27207664 Free PMC article.
Following up on this observation, bioactivation of AA-I and N-hydroxyaristolactam I (AL-I-NOH) was studied in human kidney (HK-2) and skin fibroblast (GM00637) cell lines. Pentachlorophenol, a known SULT inhibitor, significantly reduced cell death and aristolactam-DNA addu …
Following up on this observation, bioactivation of AA-I and N-hydroxyaristolactam I (AL-I-NOH) was studied in human kidney (HK-2) and ski …
Sulfation of vitamin D3 -related compounds-identification and characterization of the responsible human cytosolic sulfotransferases.
Kurogi K, Sakakibara Y, Suiko M, Liu MC. Kurogi K, et al. FEBS Lett. 2017 Aug;591(16):2417-2425. doi: 10.1002/1873-3468.12767. Epub 2017 Aug 9. FEBS Lett. 2017. PMID: 28746983 Free article.
Among the 13 human SULTs, SULT2A1 shows sulfating activity toward all vitamin D(3) -related compounds, whereas SULT1A1 and SULT2B1a/SULT2B1b show sulfating activity exclusively for, respectively, calcitriol and 7-dehydrocholesterol. These findings suggest that the metaboli …
Among the 13 human SULTs, SULT2A1 shows sulfating activity toward all vitamin D(3) -related compounds, whereas SULT1A1 and SULT2B1a/S …
Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers.
Voisin S, Almén MS, Zheleznyakova GY, Lundberg L, Zarei S, Castillo S, Eriksson FE, Nilsson EK, Blüher M, Böttcher Y, Kovacs P, Klovins J, Rask-Andersen M, Schiöth HB. Voisin S, et al. Genome Med. 2015 Oct 8;7:103. doi: 10.1186/s13073-015-0225-4. Genome Med. 2015. PMID: 26449484 Free PMC article.
For replication in other tissues, we used two open-access datasets (skin fibroblasts, n = 62; four brain regions, n = 121-133) and an additional dataset in subcutaneous and visceral fat (n = 149). ...Finally, our results indicate that some of these associations are not blo …
For replication in other tissues, we used two open-access datasets (skin fibroblasts, n = 62; four brain regions, n = 121-133) and an …
Human sulfotransferase 1A1-dependent mutagenicity of 12-hydroxy-nevirapine: the missing link?
Kranendonk M, Alves M, Antunes P, Rueff J. Kranendonk M, et al. Chem Res Toxicol. 2014 Nov 17;27(11):1967-71. doi: 10.1021/tx5003113. Epub 2014 Oct 13. Chem Res Toxicol. 2014. PMID: 25275777
Nevirapine (NVP) is a frequently used anti-HIV drug. Despite its efficacy, NVP has been associated with serious skin and liver injuries in exposed patients and with increased incidences of hepatoneoplasias in rodents. Current evidence supports the involvement of reactive m …
Nevirapine (NVP) is a frequently used anti-HIV drug. Despite its efficacy, NVP has been associated with serious skin and liver injuri …
Novel enzymatic assay predicts minoxidil response in the treatment of androgenetic alopecia.
Goren A, Castano JA, McCoy J, Bermudez F, Lotti T. Goren A, et al. Dermatol Ther. 2014 May-Jun;27(3):171-3. doi: 10.1111/dth.12111. Epub 2013 Nov 27. Dermatol Ther. 2014. PMID: 24283387
Minoxidil is converted in the scalp to its active form, minoxidil sulfate, by the sulfotransferase enzyme SULT1A1. We hypothesized that SULT1A1 enzyme activity in the hair follicle correlates with minoxidil response for the treatment of AGA. Our preliminary retrospe …
Minoxidil is converted in the scalp to its active form, minoxidil sulfate, by the sulfotransferase enzyme SULT1A1. We hypothesized th …